New
治疗
and
medications
for
asthma
become
available
for
patients
every
year,
but
it's
important
to
talk
to
你的
doctor
about
what
is
right
for
you.
I'm
Tonya
Winders,
president
and
CEO
of
Allergy
and
asthma
network
and
welcome
to
ask
the
allergist.
In
each
episode
we
present
a
frequently
asked
question
to
a
nationally
respected
allergist
and
they
share
their
insight
for
this
program.
We're
pleased
to
welcome
doctor
Rohit
Katyal.
Doctor
Katyal
is
a
board
certified
allergist
and
immunologist
as
well
as
Co
director
of
the
Asthma
Institute.
At
National
Jewish
Health
in
Denver,
colorado.
He's
also
a
member
of
the
Board
of
Regents
for
the
American
College
of
Allergy,
Asthma
and
Immunology.
Welcome,
Doctor
Katyal
good
thank.
You
for
being
here
today
so
our
question
today
actually
comes
from
a
patient
who
says
my
asthma
is
worsening.
I
recently
read
about
new
biologic
medications.
How
do
they
work
and
how
will
my
doctor
determine
if
biologics
are
right
for
me?
So
let
me
step
back
just
for
one
moment.
Asthma
is
a
disease.
Of
inflammation
of
the
breathing
tubes
and
that
inflammation
is
our
immune
cells
coming
into
the
airway
causing
them
to
get
inflamed
and
then
they
get
twitchy
and
narrow
and
we
cough
and
mucus.
And
so
that's
what
we
traditionally
see
in
asthma.
So
that's
why
in
the
past
one
of
the
main
治疗
and
still
continues
to
be
is
the
inhaled
steroids
and
they
still
are
a
great
medication
for
many
asthmatics,
the
new
biologics
that
have
now
come
to
the
market.
Target
chemicals
that
very
specifically
knockout
the
fuel
or
the
gasoline
or
the
energy
for
这些
immune
cells,
with
the
idea
being
that
if
we
knockout
the
fuel
then
those
cells
no
longer
exist
and
therefore
the
airway
doesn't
get
inflamed.
There
are
expensive,
there
are
injections
that
have
to
happen
every
month
and
so
therefore
we
still
use
the
inhalers
as
our
primary
treatment.
But
if
you're
an
asthmatic
who
continues
to
have
problems,
is
not
responding
or
still
doing
well
with
the
inhalers,
then
the
next
step
now
can
be
one
of
这些
biologics
if
you
continue
to
have
trouble
with
the
asthma
despite
the
traditional
inhaler
based
medicines.
So
as
you
were
talking
about
patients
with
those
uncontrolled
symptoms,
perhaps
they're
taking
an
inhaled
corticosteroid,
perhaps
they're
on
a
combination
Med,
but
they're
still
having
uncontrolled
symptoms
and
they're
not
doing
very
well.
With
their
symptoms,
with
their
severe
asthma,
would
you
recommend
that
they
actually
go
in
and
talk
to
their
allergist
about
the
biologics
and
if
so,
also
speak
a
little
more
about
the
administration
routes
of
those
biologics?
So
I
absolutely
recommend
that
they
go
seek
care
with
an
allergist,
not
only
to
discuss
the
new
biologics,
but
first
to
go
through
what
medications
they've
tried,
how
they've
taken
them,
the
technique,
the
inhaler,
how
long
the
doses.
Assuming
all
that's
被
done,
then
now
we
have
some
exciting
options.
In
addition,
we've
had
one
biologic,
be
aware
for
some
years,
omalizumab
is
an
injectable
biologic
that
blocks
something
called
IG,
right.
So
the
antibody
that
causes
allergy,
as
you
know,
there's
two
new
ones
called
mepolizumab,
这些
are
long
names
and
reslizumab.
And
这些
two
both
block
the
same
chemical,
got
a
long
name
called
Interleukin
5
and
that's
the
fuel
for
a
cell
called
the
Acinos
Phils,
and
that's
what
drives
the
Airways.
Breathing
tubes
to
get
inflamed.
So
the
mepolizumab
and
reslizumab
are
two
new
biologics.
The
Mepolizumab
is
an
injection
like
an
allergy
shot
or
like
the
omalizumab
has
被
in
the
arm
and
the
reslizumab
is
actually
an
intravenous
infusion.
So
an
IV
has
to
be
placed
and
the
medication
is
delivered
through
the
IV.
But
they
both
block
the
same
chemicals
and
so
they're
这些
are
very
specific
medicines.
There
are
four
severe
asthma.
But
they're
not
for
everyone,
and
that's
where
the
allergists
can
play
a
role
to
define
is
this
the
right
medication
for
you,
for
you
to
have
to
go
through
这些
monthly
administrations?
And
they
can
look
at
whether
you're
allergic
and
if
you
have
other
triggers.
So
an
allergy
评价
can
be
comprehensive,
not
only
looking
at
what
you've
taken
before,
but
really
discussing
the
risks
and
the
benefits
and
the
pros
cons
of
这些
new
medications.
好吧,
it's
exciting
to
hear
about
这些
innovations
and
the
new
options
for.
Patients,
thank
you
so
much
for
sharing
with
us.
